Issue N# 3 - 2000
Bell's palsy: treatment by association Aciclovir-Methylprednosolone, preliminary results
Authors : V. Darrouzet, S. Lacher-Fougère, J. Y. Duclos, A. Chambrin, J. P. Bébéar (Bordeaux)
Ref. : Rev Laryngol Otol Rhinol. 2000;121,3:199-202.
Article published in french
Downloadable PDF document french
Rationnal : many actual data suspect a viral etiology to Bell's palsy. Herpes viridae are more and more incriminated. On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution. Method : the evaluation concern 53 patients. We also evaluated the functionnal motor result (using House and Brackmann staging) and search pronostic factors in clinic and paraclinic data. A viral investigation have been made in most of the cases. Results : only one of our patients treated with Aciclovir keeps some sequelles (stage III of House and Brackmann classification). We didn't found any deleterious effect. Statistically, the electromyography is the only one test with a pronostic value. But we feel that delay beetween the starting and the treatment of the palsy is important. Viral tests show sometime abnormal Ig against the Herpes viridae group. Conclusions : these promising results are lightened with a review of the literature. A multicentric investigation is already in place for a stronger statistic effect.
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