Issue N# 3 - 2014
Sentinel lymph node biopsy in head and neck melanoma: A single institution analysis
Authors : Penicaud M, Cammilleri S, Giorgi R, Grob JJ, Taïeb D, Giovanni A, Dessi P, Fakhry N. (Marseille)
Ref. : Rev Laryngol Otol Rhinol. 2014;135,3:115-120.
Article published in english
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Introduction: The aim of our study was to analyze a series of patients from our institution who underwent surgery for head and neck cutaneous melanoma and who received sentinel lymph node biopsy (SLNB). Material and methods: A single-center observational cohort of 120 head and neck melanoma patients was investigated from 2002 to 2011. Results: Among the 107 patients (89.2%) with lymph node identified during lymphoscintigraphy, at least one node was collected and analyzed in 96 patients (90.6%). A positive sentinel lymph node was found in 9.4% of patients. Our data showed higher failure rate of lymphoscintigraphic identification (11.7%), lower rate of SLN positivity (9.4%), and higher false-negative rate of SLNB (24.1%) than the usual figures established for malignant melanomas in other locations. After a mean follow-up of 38.1 months, the disease-free survival (DFS) rate in the positive SLN group was 53% vs 75% for the negative SLN after 2 years of follow-up and 53% vs 48% after 5 years (p= 0.44). Conclusion: The complexity of lymphatic drainage and the anatomy of the cervical region probably accounts for a specificities which result in a lower predictive value of SLNB in head and neck melanoma than in MM in other locations.
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