Issue N# 2 - 2009
Carcinogenesis of the ethmoidal adenocarcinoma due to wood dust
Authors : De Gabory L, Conso F, Barry B, Stoll D.
Ref. : Rev Laryngol Otol Rhinol. 2009;130,2:93-104.
Article published in french
Downloadable PDF document french
Objectives: To recognize the mechanisms and the different oncogenic pathways of ethmoid adenocarcinoma (EADC) in woodworkers. Methods: A systematic review of the literature and evaluation according to scientific evidences. Results: Wood dust less than 10 µm settles on the external aspects of the ethmoid sinus that is the middle turbinate, the middle meatus and the olfactory cleft. The risk of developing an EADC is important from the first year. It is impossible to know what determines the latency period. Usually, this period exceeds 30 years and only 10% of patients are younger than 50 years of age. Chromosomal instability of the respiratory mucosa appears to be one of the major phases in the oncogenic process. Certain biomolecular and genetic factors are shared with the adenocarcinoma of the colon but they are not activated with the same importance and in the same context suggesting two distinct mechanisms of evolution. The local anatomo-clinical setting in the nasal cavity and carcinogenic substances in the wood dust play a key specific role in the development of EADC. No oncoproteins or immunohistochemistry features were identified in the process suggesting a cascade of genetic or molecular series of events.
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